e-PKGene® Pharmacogenetics Database

The Pharmacogenetics web-application (e-PKGene®) is part the drug interaction online platform powered by UW Drug Interaction Solutions.

The e-PKGene® application supports pharmaceutical scientists and clinicians in their analysis of the impact of genetic variants of enzymes and transporters on the PK, PD and safety of drugs and metabolites in various populations. Here is detailed information regarding the various DIDB® datasets:

Important features of the e-PKGene® application

  • All curation activities and editorial tasks are performed in-house.
  • Content is updated daily by research scientists with extensive expertise in gene-drug interactions (GDIs).
  • GDI data, ethnicity-drug interactions and case reports are extracted from peer-reviewed publications as well as recent NDA and BLA reviews and drug labels.
  • Detailed study information regarding design, drug dosing, genetic polymorphisms, population characteristics, PK, PD and safety results are structured and presented.
  • Common metrics are used across all studies to allow metadata analysis of quantitative results.
  • Continuous incorporation of new scientific findings and improvement of the platform functionalities.

The largest manually curated collection of drug interaction information

The e-PKGene® application was added to the UW drug interaction platform in 2010, complementing the DIDB® application introduced in 1999. The online platform has the largest manually curated collection of drug interaction information.

The DIDB® application is internationally recognized as an authoritative, unbiased, transparent research tool by its large userbase of pharmaceutical, regulatory scientists, and clinicians working at:

  • Pharmaceutical companies of all sizes
  • Regulatory agencies
  • Contract Research Organizations
  • Academics institutions
  • Non-profit organizations
  • Publishers of drug information
  • Providers of clinical decision support system
See benefits of using the UW drug interaction applications  

Access to the drug interaction online platform is licensed as an annual subscription. Licenses are obtained via UW CoMotion’s Express Licensing Program.

For more information on the program, please contact us.