The Drug Interaction Database web-application (DIDB®) is part of the drug interaction online platform powered by UW Drug Interaction Solutions.
The DIDB® application has been specifically designed to support pharmaceutical scientists and clinicians in their assessment of PK-based drug interactions and drug safety. The application contains key datasets relevant to the evaluation of drug exposure in various important clinical situations, which may involve interacting co-medications, excipients, food products, herbals, tobacco, and organ impairment. Here is detailed information regarding the various DIDB® datasets:
- Human preclinical drug metabolism
- Human preclinical drug transporter
- Clinical drug interaction
- Clinical organ impairment
Important features of the DIDB® application
- All curation activities and editorial tasks are performed in-house.
- Content is updated daily by research scientists with extensive expertise in drug-drug interactions (DDIs).
- DDI data and case reports are extracted from peer-reviewed publications as well as recent NDA and BLA reviews and drug labels.
- Inclusion of both clinical and research information allowing in vitro to in vivo extrapolations (IVIVE).
- Inclusion of negative data, critical to identify possible therapeutic options.
- Mechanistic approach: all interactions are characterized based on their mechanism(s) and studies are organized accordingly, allowing a quick retrieval and identification of a drug DDI profile. The understanding of the DDI mechanisms can then be used to make predictions beyond the observed interactions.
- Quantitative approach: the DIDB® application uses a standard metric (changes in drug exposure or oral clearance) across all citations to evaluate the impact of DDI in the clinic. Citations related to a drug or a group of drugs can then be retrieved based on these changes, allowing differentiation among drugs based on their sensitivity to inhibition/induction, and identification of the best therapeutic options.
- Detailed drug monographs are available.
- Continuous incorporation of new scientific findings and improvement of the platform functionalities.
The largest manually curated collection of drug interaction information
Established 20 years ago and complemented with the Pharmacogenetics Database (e-PKGene®) in 2010, the online platform has the largest manually curated collection of drug interaction information.
The DIDB® application is internationally recognized as an authoritative, unbiased, transparent research tool by its large userbase of pharmaceutical, regulatory scientists, and clinicians working at:
- Pharmaceutical companies of all sizes
- Regulatory agencies
- Contract Research Organizations
- Academics institutions
- Non-profit organizations
- Publishers of drug information
- Providers of clinical decision support system