February Newsletter available

The February Newsletter is now available. You can see this and past newsletters in the DIDB Resource Center. Please note that you must be signed in to access.

Do not hesitate to contact us with comments or suggestions.

DIDB Editorial Team


New “Overall Effect” for in vivo studies to include absorption-based DDIs

As a result of our continuous efforts to expand the DIDB platform coverage of pharmacokinetic-based drug interactions beyond metabolism and transport, the following new “Overall Effect” categories are now available for in vivo DDI studies:

  •                 In Vivo Other Mechanism >20% Effect
  •                 In Vivo Other Mechanism No Effect

With the following Study subtypes

  1. pH dependency (absorption)
  2. Binding/chelation (absorption)
  3. Gastrointestinal motility (absorption)
  4. Plasma protein binding displacement (distribution)
  5. Enzyme down-regulation/up-regulation reversal (metabolism)
  6. Complex/multifactorial mechanism

As we increase the number of citations pertaining to these mechanisms, you will start seeing these new studies in the queries (dropdown menus) and their results. As a first step, we entered all pH-dependent DDI evaluations (both negative and positive results) with proton pump inhibitors and we will continue adding absorption-based DDIs to the platform during the coming months.

Should you have questions, comments or concerns, please contact us at didbase@uw.edu.

DIDB Editorial Team


New User’s Tutorials

New User’s Tutorials are available in the Resource Center.


January Newsletter available

The January Newsletter is now available. You can see this and past newsletters in the DIDB Resource Center. Please note that you must be signed in to access.

Do not hesitate to contact us with comments or suggestions.

DIDB Editorial Team


December Newsletter available

The December Newsletter is now available. You can see this and past newsletters in the DIDB Resource Center. Please note that you must be signed in to access.

Do not hesitate to contact us with comments or suggestions.

DIDB Editorial Team


November Newsletter available

The November Newsletter is now available. You can see this and past newsletters in the DIDB Resource Center. Please note that you must be signed in to access.

Do not hesitate to contact us with comments or suggestions.

DIDB Editorial Team


New FDA guidance documents on DDIs available in the Resource Center

The two new FDA guidance documents on drug-drug interactions have been added to the “Regulatory Guidances” section of the DIDB Resource Center. Please note that you must be signed in to access.

  • Clinical Drug Interaction Studies (Oct. 2017). Draft Guidance
  • In Vitro Metabolism- and Transport-Mediated Drug-Drug Interaction Studies (Oct. 2017). Draft Guidance

DIDB Editorial Team


October Newsletter available

The October Newsletter is now available. You can see this and past newsletters in the DIDB Resource Center. Please note that you must be signed in to access.

Do not hesitate to contact us with comments or suggestions.

DIDB Editorial Team